Co‐delivery of docetaxel and retinoic acid by poly (ethylene glycol)‐retinoic acid conjugates based micelles for synergistic prostate cancer therapy

In the present work, docetaxel (DTX) and retinoic acid (RA) co-loaded micelles were developed for synergistic prostate cancer therapy. PEG-RA RA-PEG-RA synthesized subsequently used loading of DTX RA. The as prepared DTX/RA@RA-PEG-RA exhibit smaller size higher drug capacity compared to DTX/RA@PEG-RA micelles. in vitro release study shows that similar behaviours which exhibits fast RA sustained release. Nile red (NR) was loaded into investigate cellular uptake by fluorescence microscope flow cytometry. results show NR@RA-PEG-RA slightly enhanced NR@PEG-RA determined HPLC also results. cytotoxicity against C4-2 22Rv1 cells, combination with antitumor effect, cells DTX/RA. significant potential